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Hsiao-Huei Chen Selected Research

24-dihydroxy-5-cholestane 24-sulfate 3-N-1(spermine)-7

1/2021Tyrosine phosphatase PTP1B impairs presynaptic NMDA receptor-mediated plasticity in a mouse model of Alzheimer's disease.
1/2021Ketamine's schizophrenia-like effects are prevented by targeting PTP1B.
10/2020Activation of tyrosine phosphatase PTP1B in pyramidal neurons impairs endocannabinoid signaling by tyrosine receptor kinase trkB and causes schizophrenia-like behaviors in mice.
2/2015Functional properties of Claramine: a novel PTP1B inhibitor and insulin-mimetic compound.

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Hsiao-Huei Chen Research Topics

Disease

6Stroke (Strokes)
01/2021 - 11/2008
5Coronary Artery Disease (Coronary Atherosclerosis)
01/2021 - 01/2013
5Inflammation (Inflammations)
01/2021 - 09/2015
4Alzheimer Disease (Alzheimer's Disease)
10/2022 - 12/2020
3Schizophrenia (Dementia Praecox)
10/2022 - 10/2020
3Brain Injuries (Brain Injury)
02/2018 - 11/2008
3Ischemia
12/2010 - 08/2007
3Hypoxia (Hypoxemia)
03/2010 - 08/2007
2Cognitive Dysfunction
01/2021 - 12/2020
2Obesity
01/2021 - 07/2013
2Infarction (Infarctions)
02/2018 - 01/2017
2Atherosclerosis
01/2017 - 09/2015
2Neoplasms (Cancer)
11/2012 - 03/2010
1Breast Neoplasms (Breast Cancer)
01/2022
1Ischemic Stroke
01/2021
1Psychotic Disorders (Schizoaffective Disorder)
01/2021
1Mood Disorders (Mood Disorder)
01/2021
1Amyloidosis
12/2020
1Autistic Disorder (Autism)
01/2020
1Melanoma (Melanoma, Malignant)
02/2018
1Myocardial Ischemia (Ischemic Heart Diseases)
09/2015
1Insulin Resistance
02/2015
1Weight Loss (Weight Reduction)
02/2015
1Type 2 Diabetes Mellitus (MODY)
05/2014
1Hyperphagia (Overeating)
01/2014
1Myocardial Infarction
01/2014
1Carcinogenesis
11/2012
1Neoplasm Metastasis (Metastasis)
11/2012
1Carcinoma (Carcinomatosis)
11/2012
1Neurodegenerative Diseases (Neurodegenerative Disease)
03/2010
1Cerebral Infarction
11/2008
1Starvation
08/2007
1Cardiac Conduction System Disease
11/2004
1Hypertrophy
09/2002
1Heart Failure
09/2002

Drug/Important Bio-Agent (IBA)

5Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2021 - 01/2020
424-dihydroxy-5-cholestane 24-sulfate 3-N-1(spermine)-7IBA
01/2021 - 02/2015
4Carrier Proteins (Binding Protein)IBA
01/2021 - 01/2017
4Proteins (Proteins, Gene)FDA Link
12/2020 - 03/2010
3Tyrosine (L-Tyrosine)FDA Link
01/2021 - 10/2020
3Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA
01/2021 - 07/2013
3Interferon Regulatory Factor-2 (Interferon Regulatory Factor 2)IBA
01/2021 - 01/2017
2N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
10/2022 - 01/2021
23' Untranslated Regions (3' UTR)IBA
01/2021 - 09/2015
2EndocannabinoidsIBA
01/2021 - 10/2020
2Messenger RNA (mRNA)IBA
01/2021 - 09/2015
2Phosphotransferases (Kinase)IBA
10/2020 - 02/2018
2Neuroprotective AgentsIBA
02/2018 - 03/2010
2InterferonsIBA
01/2017 - 01/2013
1Amyloid beta-PeptidesIBA
01/2021
1salicylhydroxamic acid (SHAM)IBA
01/2021
1Antipsychotic Agents (Antipsychotics)IBA
01/2021
1KetamineFDA LinkGeneric
01/2021
1Amyloid (Amyloid Fibrils)IBA
12/2020
1Glycogen Synthase KinasesIBA
12/2020
1CannabinoidsIBA
10/2020
1CB1 Cannabinoid Receptor (CB1 Receptor)IBA
10/2020
1tyrosine receptor (receptor, tyrosine)IBA
10/2020
1ParvalbuminsIBA
01/2020
1Protein Kinases (Protein Kinase)IBA
02/2018
1Dihydrotachysterol (AT 10)IBA
02/2018
1LipopolysaccharidesIBA
02/2018
1CaspasesIBA
02/2018
1dabrafenibIBA
02/2018
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
02/2018
1Death Domain ReceptorsIBA
02/2018
1Prostaglandin D2IBA
01/2017
1CytokinesIBA
01/2017
1Interferon-betaIBA
01/2017
1erucylphosphocholineIBA
01/2017
1Transcription Factors (Transcription Factor)IBA
11/2015
1Transforming Growth Factors (Transforming Growth Factor)IBA
11/2015
1ApolipoproteinsIBA
09/2015
1Interferon Regulatory FactorsIBA
09/2015
1CholesterolIBA
09/2015
1LDL Receptors (LDL Receptor)IBA
09/2015
1claramineIBA
02/2015
1Glutamine (L-Glutamine)FDA Link
05/2014
1Arginine (L-Arginine)FDA Link
05/2014
1LDL CholesterolIBA
01/2014
1Calcium Channels (Calcium Channel)IBA
01/2014
1LeptinIBA
07/2013
1Oncogene Proteins (Oncogene Protein)IBA
11/2012
1Tumor Biomarkers (Tumor Markers)IBA
11/2012
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
11/2012
1Shc Signaling Adaptor ProteinsIBA
11/2012
1Histone Deacetylase 2IBA
03/2010
1Granulocyte Colony-Stimulating Factor (G-CSF)IBA
03/2010
1PPAR gammaIBA
11/2008
1Purinergic Receptors (Receptors, Purine)IBA
08/2007
1Adenosine Triphosphate (ATP)IBA
08/2007
1ConnexinsIBA
11/2004
1Co-Repressor ProteinsIBA
09/2002

Therapy/Procedure

3Therapeutics
01/2022 - 11/2012
1Glycemic Control
02/2015